Description

3-(Difluoromethyl)-2-Fluoropyridine CAS NO 1374659-42-3 is a high-purity fluorinated pyridine derivative, a key building block in advanced organic synthesis. Its unique difluoromethyl and fluorine substituents make it a valuable intermediate for introducing fluorine atoms into target molecules, a critical step in modern pharmaceutical and agrochemical development. This compound is essential for researchers and manufacturers in the life sciences sector seeking to enhance the metabolic stability, bioavailability, and binding affinity of novel compounds.

Application

• Pharmaceutical Intermediate: A crucial synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where fluorine incorporation improves efficacy and environmental profile.
• Material Science: Serves as a precursor for specialty polymers, liquid crystals, and electronic chemicals requiring specific fluorinated aromatic structures.
• Chemical Research & Development: A versatile reagent in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization programs.
• Fluorine Chemistry: Employed in methodological development for novel fluorination and difluoromethylation reactions.

Basic Information

Product Name	3-(Difluoromethyl)-2-Fluoropyridine
CAS No.	1374659-42-3
Molecular Formula	C6H4F3N
Molecular Weight	147.10 g/mol
Synonyms	2-Fluoro-3-(difluoromethyl)pyridine; 3-(Difluoromethyl)-2-fluoropyridine; 2-Fluoro-3-difluoromethylpyridine; Pyridine, 2-fluoro-3-(difluoromethyl)-; 1374659-42-3; 2-Fluoro-3-difluoromethyl-pyridine
EINECS	Contact for details

Quality Control

Our 3-(Difluoromethyl)-2-Fluoropyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification parameters. Our quality commitment ensures material consistency and reliability for your critical R&D and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.