Description

5-(Difluoromethyl)-2-Fluoropyridine is a high-value, multi-functional fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique difluoromethyl and fluorine substituents make it an essential intermediate for introducing fluorine atoms into target molecules, a key strategy in modern pharmaceutical and agrochemical design. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty materials industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting kinase inhibitors, CNS agents, and anti-infectives where fluorination modulates bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, where the difluoromethyl group can enhance biological activity and environmental profile.
• Ligand & Catalyst Development: Serves as a precursor for synthesizing novel fluorinated ligands used in catalysis, enabling more efficient and selective chemical transformations.
• Material Science Research: Employed in the creation of fluorinated polymers, liquid crystals, and electronic materials to impart specific properties like chemical resistance, thermal stability, or unique optical characteristics.
• Fluorine-18 Radiochemistry: A potential precursor for positron emission tomography (PET) tracer development, given its fluoropyridine core which can be utilized in labeling strategies.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	5-(Difluoromethyl)-2-Fluoropyridine
CAS No.	1374659-41-2
Molecular Formula	C6H4F3N
Molecular Weight	147.10 g/mol
Synonyms	2-Fluoro-5-(difluoromethyl)pyridine; 5-(Difluoromethyl)-2-fluoropyridine; 2-Fluoro-5-difluoromethylpyridine; Pyridine, 5-(difluoromethyl)-2-fluoro-; 1374659-41-2
EINECS	Contact for details

Quality Control

Every batch of 5-(Difluoromethyl)-2-Fluoropyridine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements of research and process chemistry. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as purity (by GC/HPLC), identity (by NMR, IR), and impurity profile. Our quality commitment supports compliance with cGMP and ICH Q7 guidelines where applicable for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its chemical nature, keep away from strong bases and incompatible materials. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.