Description

2,3-Difluoro-4-(Difluoromethyl)Pyridine is a high-value, multi-fluorinated pyridine derivative serving as a critical building block in advanced chemical synthesis. Its unique structure, featuring a difluoromethyl group adjacent to fluorine atoms on the pyridine ring, makes it an essential precursor for introducing fluorinated motifs into target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in oncology and central nervous system (CNS) drug discovery programs where fluorination improves metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides, fungicides, and insecticides, where the difluoromethylpyridine moiety can enhance biological activity and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized fluorinated ligands used in catalysis and material science applications.
• Organic Electronic Materials: Investigated as a building block for fluorinated components in organic semiconductors and other advanced materials.
• Custom Synthesis and Contract Manufacturing: Supplied to fine chemical companies engaged in custom synthesis for clients in life sciences.
• Academic and Industrial R&D: Utilized in research laboratories for methodological development and exploring new chemical spaces in fluorochemistry.

Basic Information

Item	Details
Product Name	2,3-Difluoro-4-(Difluoromethyl)Pyridine
CAS No.	1374659-38-7
Molecular Formula	C7H4F4N
Molecular Weight	178.11 g/mol
Synonyms	4-(Difluoromethyl)-2,3-difluoropyridine; 2,3-Difluoro-4-(difluoromethyl)pyridine; Pyridine, 2,3-difluoro-4-(difluoromethyl)-; 1374659-38-7
EINECS	Contact for details

Quality Control

Every batch of 2,3-Difluoro-4-(Difluoromethyl)Pyridine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements of your synthesis. Standard quality verification includes HPLC for purity and GC-MS, 1H/19F NMR for structural confirmation. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (typically 15-25°C). Keep away from strong bases and incompatible materials. Due to its fluoride content, ensure containers are properly sealed and handled with appropriate engineering controls to minimize exposure.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.