Description

3-(Difluoromethyl)-5-Fluoro-Pyridine is a high-value fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique difluoromethyl and fluoro substituents make it an essential intermediate for introducing fluorine atoms into target molecules, a key strategy in modern agrochemical and pharmaceutical development. This compound is primarily sought by R&D chemists and process development scientists in the life sciences sector for creating novel active ingredients with enhanced properties.

Application

• Pharmaceutical Intermediate: Key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in CNS and oncology research.
• Agrochemical Synthesis: Used in the manufacture of advanced herbicides, fungicides, and insecticides where fluorine substitution improves efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of fluorinated polymers and liquid crystals with unique electronic and surface properties.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	3-(Difluoromethyl)-5-Fluoro-Pyridine
CAS No.	1374659-37-6
Molecular Formula	C6H4F3N
Molecular Weight	147.10 g/mol
Synonyms	5-Fluoro-3-(difluoromethyl)pyridine; 3-Difluoromethyl-5-fluoropyridine; 5-Fluoro-3-difluoromethylpyridine; Pyridine, 5-fluoro-3-(difluoromethyl)-; 1374659-37-6
EINECS	Contact for details

Quality Control

Our 3-(Difluoromethyl)-5-Fluoro-Pyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with agreed specifications. We support cGMP standards for pharmaceutical applications and can accommodate custom purity requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions or inert atmosphere to maintain stability. Keep away from strong bases and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.