Description

4-(Difluoromethyl)-3-Fluoropyridine CAS NO 1374659-35-4 is a high-value, multi-fluorinated pyridine derivative serving as a critical building block in advanced organic synthesis. Its unique structure, featuring both difluoromethyl and fluorine substituents, is engineered to modulate the lipophilicity, metabolic stability, and binding affinity of target molecules. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients with enhanced properties.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and central nervous system (CNS) targeted drugs.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides and fungicides, where the fluorine atoms contribute to improved bioavailability and environmental persistence.
• Material Science Precursor: Employed in the synthesis of specialty chemicals, liquid crystals, and advanced polymers requiring specific fluorine-based electronic properties.
• Chemical Research & Development: Serves as a versatile scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and library synthesis.
• Fluorine Chemistry Building Block: Utilized in cross-coupling reactions, nucleophilic substitutions, and other transformations to introduce complex fluorinated motifs.

Basic Information

Product Name	4-(Difluoromethyl)-3-Fluoropyridine
CAS No.	1374659-35-4
Molecular Formula	C6H4F3N
Molecular Weight	147.10 g/mol
Synonyms	3-Fluoro-4-(difluoromethyl)pyridine; 4-(Difluoromethyl)-3-fluoropyridine; 3-Fluoro-4-difluoromethylpyridine; Pyridine, 4-(difluoromethyl)-3-fluoro-; 1374659-35-4
EINECS	Contact for details

Quality Control

Every batch of 4-(Difluoromethyl)-3-Fluoropyridine is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the precise requirements of your synthesis. Our standard quality control includes HPLC purity analysis, NMR identification, and residual solvent testing. A detailed Certificate of Analysis (COA) is supplied with each shipment, and we support compliance with REACH and other global regulatory frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its highly volatile nature, ensure containers are kept sealed when not in use and stored away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.