Description

tert-Butyl 2-Bromo-5-Fluoropyridin-4-Ylcarbamate is a high-purity, advanced pharmaceutical intermediate characterized by its bromo-fluoro-pyridine core protected by a tert-butyl carbamate group. This compound matters as a critical building block for medicinal chemists, enabling the synthesis of complex molecules with precise regiochemistry for drug discovery and development. It is primarily needed by R&D and production teams in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Research: Used in the development of new herbicides and pesticides, leveraging the bioactivity of the halogenated pyridine scaffold.
• Chemical Biology: Serves as a versatile precursor for creating molecular probes and labeled compounds for biological studies.
• Material Science: Potential building block for functionalized ligands in catalysis or for creating specialty polymers.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting outsourced drug discovery and custom synthesis projects.

Basic Information

Product Name	tert-Butyl 2-Bromo-5-Fluoropyridin-4-Ylcarbamate
CAS No.	1374651-93-0
Molecular Formula	C10H12BrFN2O2
Molecular Weight	291.12 g/mol
Synonyms	tert-Butyl N-(2-bromo-5-fluoropyridin-4-yl)carbamate; 4-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-bromo-5-fluoropyridine; 2-Bromo-5-fluoro-4-pyridinylcarbamic acid 1,1-dimethylethyl ester; 2-Bromo-5-fluoropyridin-4-yl-carbamic acid tert-butyl ester; BOC-2-Bromo-5-fluoropyridin-4-ylamine; tert-Butyl (2-bromo-5-fluoropyridin-4-yl)carbamate
EINECS	Contact for details

Quality Control

Our tert-Butyl 2-Bromo-5-Fluoropyridin-4-Ylcarbamate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.