Description

5-Fluoropyridin-2-Ylmagnesium Bromide is a highly reactive organometallic reagent, specifically a Grignard reagent, essential for constructing complex fluorinated heterocyclic frameworks. Its core value lies in enabling the efficient introduction of the 5-fluoro-2-pyridyl moiety into target molecules, a key structural motif in advanced chemical synthesis. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) containing fluoropyridine rings, particularly in oncology and central nervous system (CNS) drug candidates.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the fluoropyridine group enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Materials Chemistry: Employed in the synthesis of fluorinated organic electronic materials, such as those used in OLEDs and semiconductors.
• Cross-Coupling Reactions: A vital reagent in Kumada, Negishi, and other transition-metal-catalyzed cross-coupling reactions to form carbon-carbon bonds.
• Nucleophilic Aromatic Substitution: Facilitates the functionalization of various electrophilic aromatic systems.

Basic Information

Item	Details
Product Name	5-Fluoropyridin-2-Ylmagnesium Bromide
CAS No.	1374567-99-3
Molecular Formula	C5H3BrFMgN
Molecular Weight	200.29 g/mol
Synonyms	2-Bromo-5-fluoropyridine magnesium bromide; 5-Fluoro-2-pyridylmagnesium bromide; (5-Fluoropyridin-2-yl)magnesium bromide; Magnesium, bromo(5-fluoro-2-pyridinyl)-; 5-Fluoro-2-pyridyl Grignard reagent; 5-Fluoropyridine-2-magnesium bromide; 2-Pyridinemagnesium bromide, 5-fluoro-
EINECS	Contact for details

Quality Control

Every batch of 5-Fluoropyridin-2-Ylmagnesium Bromide is manufactured and tested under stringent quality management systems. We provide comprehensive analytical data to ensure consistency and reliability for your critical synthetic steps. Certificates of Analysis (COA) detailing purity, concentration, and solvent are available for each lot upon request, supporting compliance in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Due to its highly reactive, moisture-sensitive, and pyrophoric nature, this reagent must be stored under an inert atmosphere (argon or nitrogen) at recommended temperatures, typically between 2°C and 8°C for extended stability. Handle and store away from moisture, oxygen, and incompatible materials.

Specification

Item	Specification
Appearance	Solution (typically in THF or Diethyl Ether)
Concentration	0.5 M in THF (or as specified)
Assay (Titration)	≥ 95%
Purity (GC/HPLC)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.