Description

4-Fluoro-3-Methyl-5-(Trifluoromethyl)Benzyl Bromide, 97% is a high-purity, multi-functional benzyl bromide derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic placement of fluorine and trifluoromethyl groups, which are essential for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of fluorinated drugs targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the fluorine and trifluoromethyl groups enhance biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor for fluorinated aromatic compounds used in electronic display technologies and organic light-emitting diodes.
• Polymer Modification: Employed to introduce fluorine-containing benzyl groups into polymer chains, altering surface properties, chemical resistance, and thermal stability.
• Cross-Coupling Reactions: A versatile substrate for palladium-catalyzed reactions like Suzuki-Miyaura and Stille couplings to construct complex biaryl systems.
• Material Science Research: Used in academic and industrial R&D for developing new fluorinated aromatic compounds with specialized optical or electronic properties.

Basic Information

Product Name	4-Fluoro-3-Methyl-5-(Trifluoromethyl)Benzyl Bromide, 97%
CAS No.	1373921-09-5
Molecular Formula	C9H7BrF4
Molecular Weight	271.05 g/mol
Synonyms	1-(Bromomethyl)-4-fluoro-3-methyl-5-(trifluoromethyl)benzene; α-Bromo-4-fluoro-3-methyl-5-(trifluoromethyl)toluene; (4-Fluoro-3-methyl-5-(trifluoromethyl)phenyl)methyl bromide; 4-Fluoro-3-methyl-5-trifluoromethylbenzyl bromide; 5-(Bromomethyl)-1-fluoro-2-methyl-3-(trifluoromethyl)benzene; 2-Fluoro-6-methyl-4-(trifluoromethyl)benzyl bromide; 3-Methyl-4-fluoro-5-(trifluoromethyl)benzyl bromide
EINECS	Contact for details

Quality Control

Our 4-Fluoro-3-Methyl-5-(Trifluoromethyl)Benzyl Bromide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced techniques including HPLC, GC, and NMR to confirm identity and assay. Certificates of Analysis (COA) detailing all specification parameters are provided and available upon request. Our quality system is designed to support cGMP requirements for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Any single impurity	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.