Description

2-Bromobenzenesulfonyl Fluoride is a versatile and highly reactive organosulfur compound, serving as a critical building block in advanced organic synthesis. Its value lies in the unique combination of the sulfonyl fluoride moiety, a powerful "click chemistry" handle, and the bromine substituent, which enables further functionalization via cross-coupling reactions. This bifunctional reagent is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for the development of covalent inhibitors, proteolysis-targeting chimeras (PROTACs), and novel material precursors.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of covalent drug candidates targeting serine hydrolases and other enzymes.
• Chemical Biology Probe Development: Used for activity-based protein profiling (ABPP) and the creation of sulfonyl fluoride-based probes for target identification.
• Agrochemical Synthesis: Building block for novel herbicides, fungicides, and insecticides requiring sulfonamide or sulfonate ester functionalities.
• Material Science: Monomer or cross-linking agent in the production of specialty polymers and functionalized surfaces.
• Suzuki & Other Cross-Coupling Reactions: The bromine atom allows for efficient palladium-catalyzed coupling to introduce complex aryl groups.
• Sulfur(VI) Fluoride Exchange (SuFEx) Chemistry: A prime substrate for this next-generation click chemistry, enabling robust bioconjugation and polymer linkage.

Basic Information

Product Name	2-Bromobenzenesulfonyl Fluoride
CAS No.	1373232-47-3
Molecular Formula	C6H4BrFO2S
Molecular Weight	239.06 g/mol
Synonyms	o-Bromobenzenesulfonyl Fluoride; 1-Bromo-2-(fluorosulfonyl)benzene; Benzenesulfonyl fluoride, 2-bromo-; 2-Bromophenylsulfonyl fluoride; (2-Bromophenyl)sulfonyl fluoride; 2-Bromo-1-fluorosulfonylbenzene; 2-Bromobenzene-1-sulfonyl fluoride
EINECS	Contact for details

Quality Control

Our 2-Bromobenzenesulfonyl Fluoride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your R&D and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent hydrolysis. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.