Description

2-Ethynyl-5-Fluoro-3-Methylpyridine is a high-value, multi-functional heterocyclic building block characterized by its unique ethynyl and fluoro substituents. This compound matters for its critical role as a key intermediate in the synthesis of complex molecules, particularly in advanced pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing novel active compounds and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides and pesticides, leveraging its fluorine atom for enhanced biological activity and metabolic stability.
• Material Science Precursor: Serves as a building block for advanced organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, due to its conjugated ethynyl group.
• Cross-Coupling Reactions: The ethynyl group makes it an excellent substrate for Sonogashira, Click Chemistry, and other palladium-catalyzed cross-coupling reactions to create complex molecular architectures.
• Ligand Synthesis: Utilized in the preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Fluorinated Compound Library: An essential component in combinatorial chemistry for generating diverse fluorinated compound libraries for high-throughput screening.

Basic Information

Product Name	2-Ethynyl-5-Fluoro-3-Methylpyridine
CAS No.	1372103-93-9
Molecular Formula	C8H6FN
Molecular Weight	135.14 g/mol
Synonyms	5-Fluoro-3-methyl-2-ethynylpyridine; 2-Ethynyl-5-fluoro-3-picoline; 3-Methyl-5-fluoro-2-ethynylpyridine; 2-Pyridineacetonitrile, 5-fluoro-3-methyl-; 5-Fluoro-3-methylpyridin-2-ylacetylene; 2-Ethynyl-5-fluoro-3-methyl-pyridine; (5-Fluoro-3-methylpyridin-2-yl)ethyne
EINECS	Contact for details

Quality Control

Our 2-Ethynyl-5-Fluoro-3-Methylpyridine is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided and available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed under an inert atmosphere if prolonged storage is required to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.