Description

5-(Bromomethyl)-2-(4-Trifluoromethoxyphenyl)Pyridine is a high-value, multi-functional organic building block featuring both a reactive bromomethyl group and a trifluoromethoxy-substituted aromatic system. This compound is critical for medicinal chemistry and advanced materials research, enabling the precise introduction of complex molecular fragments. It is primarily sought after by pharmaceutical R&D teams and fine chemical manufacturers for the synthesis of novel active pharmaceutical ingredients (APIs) and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of small molecule drug candidates, particularly in kinase inhibitor and CNS-targeted therapeutic research.
• Agrochemical Synthesis: Used to construct advanced pyridine-based molecules for the development of new herbicides and fungicides.
• Ligand and Catalyst Development: Serves as a versatile scaffold for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science: Incorporated into the design of organic semiconductors, liquid crystals, and other functional organic materials due to its electron-withdrawing trifluoromethoxy group.
• Chemical Biology Probes: Utilized for labeling and modifying biomolecules, aiding in the study of biological pathways and target engagement.
• Cross-Coupling Reactions: The bromomethyl moiety acts as an excellent handle for further functionalization via Suzuki, Sonogashira, or other palladium-catalyzed cross-coupling reactions.

Basic Information

Product Name	5-(Bromomethyl)-2-(4-Trifluoromethoxyphenyl)Pyridine
CAS No.	1370025-51-6
Molecular Formula	C14H11BrF3NO
Molecular Weight	346.14 g/mol
Synonyms	2-(4-(Trifluoromethoxy)phenyl)-5-(bromomethyl)pyridine; 5-(Bromomethyl)-2-[4-(trifluoromethoxy)phenyl]pyridine; 2-(4-Trifluoromethoxyphenyl)-5-bromomethylpyridine; 5-Bromomethyl-2-(4-trifluoromethoxyphenyl)pyridine; [4-(5-Bromomethyl-pyridin-2-yl)-phenyl]-trifluoromethyl ether; 1370025-51-6
EINECS	Contact for details

Quality Control

Our 5-(Bromomethyl)-2-(4-Trifluoromethoxhenyl)Pyridine is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and GC-MS for impurity profiling, to ensure it meets the stringent requirements of research and development. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting the specific results for that lot.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.