Description

1-Bromo-4-(tert-Butyl)-2-Fluorobenzene is a high-purity halogenated aromatic building block of significant importance in advanced organic synthesis. Its value lies in the strategic positioning of bromine and fluorine substituents on a tert-butyl benzene scaffold, enabling precise molecular modifications. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, leveraging the biological activity of fluorinated and brominated aromatics.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the creation of novel organic electronic materials, liquid crystals, and polymers where halogenated tert-butyl benzenes impart specific electronic and steric properties.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions due to the reactive bromine moiety.
• Chemical Library Synthesis: A valuable building block for constructing diverse compound libraries in high-throughput screening and drug discovery.

Basic Information

Product Name	1-Bromo-4-(tert-Butyl)-2-Fluorobenzene
CAS No.	1369829-80-0
Molecular Formula	C10H12BrF
Molecular Weight	231.11 g/mol
Synonyms	4-tert-Butyl-2-fluorobromobenzene; 2-Fluoro-4-tert-butylbromobenzene; 1-Bromo-4-tert-butyl-2-fluorobenzene; 4-(tert-Butyl)-2-fluorobromobenzene; 2-Fluoro-1-bromo-4-tert-butylbenzene; p-tert-Butyl-o-fluorobromobenzene; Benzene, 1-bromo-4-(1,1-dimethylethyl)-2-fluoro-; 1369829-80-0
EINECS	Contact for details

Quality Control

Our 1-Bromo-4-(tert-Butyl)-2-Fluorobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are available upon request, supporting compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.