Description

3-(2,2,2-Trifluoro-Ethoxy)-Benzenesulfonyl Chloride is a high-purity, advanced pharmaceutical intermediate and versatile chemical building block. Its core value lies in its trifluoroethoxy-substituted benzenesulfonyl chloride structure, which is critical for introducing specific physicochemical properties into target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries engaged in the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, metabolic diseases, and inflammation.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the sulfonyl chloride moiety enables the creation of sulfonamide and sulfonate derivatives.
• Material Science: Serves as a precursor for functional polymers, liquid crystals, and advanced organic electronic materials due to its electron-withdrawing trifluoroethoxy group.
• Chemical Biology & Proteomics: Acts as a reactive handle for bioconjugation and the development of activity-based probes and covalent inhibitors.
• Dye & Pigment Industry: Employed in the synthesis of specialized dyes and pigments requiring sulfonated structures for enhanced solubility and color fastness.
• Custom Synthesis & Contract Manufacturing: A critical reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving global R&D projects.

Basic Information

Product Name	3-(2,2,2-Trifluoro-Ethoxy)-Benzenesulfonyl Chloride
CAS No.	1365941-75-8
Molecular Formula	C8H6ClF3O3S
Molecular Weight	274.64 g/mol
Synonyms	1-(2,2,2-Trifluoroethoxy)-3-(chlorosulfonyl)benzene; m-(2,2,2-Trifluoroethoxy)benzenesulfonyl chloride; 3-(2,2,2-Trifluoroethoxy)benzene-1-sulfonyl chloride; Benzenesulfonyl chloride, 3-(2,2,2-trifluoroethoxy)-; 3-Trifluoroethoxybenzenesulfonyl chloride; (3-(Trifluoroethoxy)phenyl)sulfonyl chloride
EINECS	Contact for details

Quality Control

Our 3-(2,2,2-Trifluoro-Ethoxy)-Benzenesulfonyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high purity and batch-to-batch consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.