Description

6-(Trifluoromethyl)-3,4-Dihydroisoquinolin-1(2H)-One is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core structure, featuring the isoquinolinone scaffold and a strategically positioned trifluoromethyl group, makes it a critical intermediate for developing novel bioactive molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries. Its unique properties facilitate the creation of compounds with enhanced metabolic stability, lipophilicity, and binding affinity.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of potential drug candidates, particularly for central nervous system (CNS) targets, kinase inhibitors, and anti-inflammatory agents.
• Agrochemical Research: Used in developing new active ingredients for crop protection, where the trifluoromethyl group can improve biological activity and environmental stability.
• Material Science: Investigated as a building block for specialty polymers and advanced organic electronic materials due to its fluorine content and rigid heterocyclic structure.
• Chemical Biology: Employed as a molecular probe or scaffold in medicinal chemistry for structure-activity relationship (SAR) studies and hit-to-lead optimization.
• Fluorine Chemistry: A valuable substrate for further functionalization, enabling the exploration of new fluorinated chemical space in discovery chemistry.

Basic Information

Product Name	6-(Trifluoromethyl)-3,4-Dihydroisoquinolin-1(2H)-One
CAS No.	1365760-11-7
Molecular Formula	C10H8F3NO
Molecular Weight	215.17 g/mol
Synonyms	6-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinolin-1-one; 1(2H)-Isoquinolinone, 3,4-dihydro-6-(trifluoromethyl)-; 6-Trifluoromethyl-3,4-dihydro-1H-isoquinolin-1-one; 6-Trifluoromethyl-1,2,3,4-tetrahydroisoquinolin-1-one; 6-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline-1-one
EINECS	Contact for details

Quality Control

Every batch of 6-(Trifluoromethyl)-3,4-Dihydroisoquinolin-1(2H)-One is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and development applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment. Our quality protocols are designed to support cGMP and ISO-guided workflows for critical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.