Description

5-Bromo-2-Fluoro-3-(Trifluoromethyl)Pyridine is a high-value, multi-halogenated pyridine derivative serving as a critical building block in advanced organic synthesis. Its unique structure, featuring bromine, fluorine, and a trifluoromethyl group, makes it an indispensable intermediate for introducing specific steric and electronic properties into target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: Key synthon for the development of new drug candidates, particularly in kinase inhibitor and central nervous system (CNS) active compound research.
• Agrochemical Synthesis: Used in the creation of advanced herbicides, fungicides, and insecticides where the fluorine and trifluoromethyl groups enhance biological activity and environmental stability.
• Material Science Research: Serves as a precursor for synthesizing functionalized ligands, liquid crystals, and other specialty organic materials.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to construct complex biaryl systems.
• Fluorinated Compound Libraries: Essential for medicinal chemistry programs focused on building screening libraries with fluorinated analogs to improve metabolic stability and membrane permeability.

Basic Information

Product Name	5-Bromo-2-Fluoro-3-(Trifluoromethyl)Pyridine
CAS No.	1365262-75-4
Molecular Formula	C7H2BrF4N
Molecular Weight	243.99 g/mol
Synonyms	5-Bromo-2-fluoro-3-(trifluoromethyl)pyridine; 2-Fluoro-5-bromo-3-(trifluoromethyl)pyridine; 3-(Trifluoromethyl)-5-bromo-2-fluoropyridine; 1365262-75-4; 5-Bromo-2-fluoro-3-trifluoromethylpyridine
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-Fluoro-3-(Trifluoromethyl)Pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and incompatible materials. The compound is light-sensitive and should be stored away from light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.