Description

2-Methyl-2H-Indazole-6-Sulfonyl Chloride is a high-purity sulfonyl chloride derivative, a critical building block in modern synthetic chemistry. Its primary value lies in its role as a versatile electrophilic reagent for introducing the sulfonamide moiety, enabling the synthesis of complex molecules with targeted biological activity. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly those focused on creating new small-molecule drug candidates, enzyme inhibitors, and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting kinases and other enzymes where the sulfonamide group is a critical pharmacophore.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and pesticides that require sulfonamide-based active ingredients.
• Chemical Biology & Proteomics: Serves as a reactive handle for activity-based protein profiling (ABPP) and the development of chemical probes to study enzyme function.
• Material Science Research: Employed in the creation of specialized polymers and advanced organic materials with specific sulfonated functionalities.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke synthesis projects requiring high-purity, specialized intermediates.

Basic Information

Product Name	2-Methyl-2H-Indazole-6-Sulfonyl Chloride
CAS No.	1363381-94-5
Molecular Formula	C8H7ClN2O2S
Molecular Weight	230.67 g/mol
Synonyms	6-(Chlorosulfonyl)-2-methyl-2H-indazole; 2-Methyl-1H-indazole-6-sulfonyl chloride; 2-Methyl-2H-indazole-6-sulfonyl chloride; 1-Methyl-1H-indazole-6-sulfonyl chloride; Indazole-6-sulfonyl chloride, 2-methyl-; 1363381-94-5; 2-Methylindazole-6-sulfonyl chloride
EINECS	Contact for details

Quality Control

Every batch of 2-Methyl-2H-Indazole-6-Sulfonyl Chloride is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided with each shipment to guarantee compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.