Description

6-Bromo-2-Methyl-2H-Indazole-3-Sulfonyl Chloride is a high-value, multi-functional chemical building block essential for modern synthetic chemistry. Its core value lies in its dual functionality as both a halogenated heterocycle and a highly reactive sulfonyl chloride, enabling efficient derivatization and the construction of complex molecular architectures. This compound is primarily needed by research and development chemists in the pharmaceutical, agrochemical, and advanced materials sectors for applications such as medicinal chemistry, chemical biology, and the synthesis of functional dyes.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in kinase inhibitor and protease inhibitor research.
• Agrochemical Synthesis: Used to create advanced active ingredients for crop protection products, leveraging its halogen and sulfonyl groups for structural diversity.
• Chemical Biology Probe Development: Serves as a versatile scaffold for creating activity-based probes (ABPs) and photoaffinity labels to study enzyme function and protein interactions.
• Functional Material Building Block: Employed in the synthesis of organic electronic materials, dyes, and pigments due to the electron-withdrawing sulfonyl group and the modifiable indazole core.
• Sulfonamide Library Synthesis: The reactive sulfonyl chloride group is ideal for high-throughput parallel synthesis to generate diverse sulfonamide libraries for screening.
• Peptidomimetic Chemistry: Incorporated into peptide backbones to enhance metabolic stability and modulate physicochemical properties of peptide-based therapeutics.

Basic Information

Product Name	6-Bromo-2-Methyl-2H-Indazole-3-Sulfonyl Chloride
CAS No.	1363380-61-3
Molecular Formula	C8H6BrClN2O2S
Molecular Weight	309.57 g/mol
Synonyms	6-Bromo-2-methyl-2H-indazole-3-sulfonyl chloride; 2H-Indazole-3-sulfonyl chloride, 6-bromo-2-methyl-; 6-Bromo-2-methylindazole-3-sulfonyl chloride; 6-Bromo-2-methyl-1H-indazole-3-sulfonyl chloride; 1363380-61-3; 6-Bromo-2-methyl-2H-indazole-3-sulphonyl chloride
EINECS	Contact for details

Quality Control

Our 6-Bromo-2-Methyl-2H-Indazole-3-Sulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and process development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.