Description

2-Fluoro-4-Methylpyridine-5-Boronic Acid Pinacol Ester is a high-value, organoboron building block essential for modern synthetic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for creating novel active ingredients and functional compounds.

Application

• Pharmaceutical Intermediate: A key synthon for constructing fluorinated pyridine cores in active pharmaceutical ingredients (APIs), leveraging the Suzuki reaction for efficient library synthesis and lead optimization.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the fluorinated methylpyridine moiety imparts desirable biological activity and metabolic stability.
• Material Science Research: Serves as a precursor for creating functionalized organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) with tailored electronic or photophysical properties.
• Chemical Biology & Probe Development: Employed in the synthesis of fluorinated molecular probes and tags for imaging, diagnostics, and studying biological pathways.
• Cross-Coupling Methodology: A reliable reagent in methodological studies and scale-up processes for palladium-catalyzed coupling reactions in both academic and industrial settings.

Basic Information

Product Name	2-Fluoro-4-Methylpyridine-5-Boronic Acid Pinacol Ester
CAS No.	1363192-17-9
Molecular Formula	C₁₂H₁₇BFNO₂
Molecular Weight	237.08 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-fluoro-4-methylpyridine; 2-Fluoro-4-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; (2-Fluoro-4-methylpyridin-5-yl)boronic acid pinacol ester; 2-Fluoro-4-methylpyridine-5-boronic acid pinacol ester; 2-Fluoro-4-methyl-5-pyridineboronic acid pinacol ester; 5-Boronic acid, 2-fluoro-4-methylpyridine-, pinacol ester
EINECS	Contact for details

Quality Control

Every batch of 2-Fluoro-4-Methylpyridine-5-Boronic Acid Pinacol Ester is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for sensitive cross-coupling applications. A detailed Certificate of Analysis (COA) confirming identity, purity (typically ≥95% by HPLC), and impurity profile is supplied with each shipment to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 0.5%
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.