Description

Seletalisib CAS NO 1362850-20-1 is a potent and selective small molecule inhibitor of the delta isoform of phosphoinositide 3-kinase (PI3Kδ). This compound matters as a critical research tool and pharmaceutical intermediate for developing targeted therapies in oncology and inflammatory diseases. It is primarily needed by pharmaceutical R&D departments, biotechnology companies, and academic research institutions focused on immuno-oncology, hematological malignancies, and autoimmune disorder research.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced investigational drugs targeting PI3Kδ pathways.
• Biochemical Research: A selective tool compound for studying the role of PI3Kδ in B-cell activation, proliferation, and survival in vitro and in vivo.
• Preclinical Development: Used in the development and optimization of therapeutic candidates for cancers such as chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma.
• Immunology Studies: Facilitates research into inflammatory and autoimmune conditions like rheumatoid arthritis and asthma by modulating immune cell signaling.
• High-Throughput Screening (HTS): Serves as a reference standard and positive control in assay development and compound library screening.
• Mechanism of Action (MoA) Studies: Enables detailed pharmacological profiling to understand drug-target interactions and downstream effects.

Basic Information

Product Name	Seletalisib
CAS No.	1362850-20-1
Molecular Formula	C₂₃H₂₀N₆O₂
Molecular Weight	412.45 g/mol
Synonyms	UCB-5857; Seletalisib (UCB5857); 5-(2,6-Di-4-morpholinyl-4-pyrimidinyl)-4-(trifluoromethyl)-2-pyridinamine; 4-(Trifluoromethyl)-5-[2,6-di(4-morpholinyl)-4-pyrimidinyl]-2-pyridinamine; 5-[2,6-Bis(4-morpholinyl)-4-pyrimidinyl]-4-(trifluoromethyl)-2-pyridinamine; PI3Kδ inhibitor UCB-5857; UCB 5857; UCB5857
EINECS	Contact for details

Quality Control

Our Seletalisib is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent control of residual solvents and impurities. Certificates of Analysis (COA) detailing all specifications are provided to ensure compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider desiccants or an inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.