Description

Ck2 Inhibitor 10 is a potent and selective small molecule inhibitor of casein kinase 2 (CK2), a serine/threonine kinase implicated in numerous cellular processes. This high-purity compound is essential for biochemical and pharmacological research targeting CK2-dependent signaling pathways in disease models. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on oncology, neurology, and inflammatory disease research.

Application

• Biochemical Research: Used as a selective tool compound to study CK2 enzyme kinetics, substrate phosphorylation, and pathway modulation in in vitro assays.
• Cell-Based Studies: Applied in cell culture to investigate the role of CK2 in cellular processes such as proliferation, apoptosis, and DNA damage response.
• Drug Discovery & Development: Serves as a key reference standard and lead compound in preclinical programs for cancers, neurodegenerative diseases, and viral infections where CK2 is a therapeutic target.
• Mechanistic Pharmacology: Employed to validate CK2 as a drug target and to understand resistance mechanisms in various disease models.
• High-Throughput Screening (HTS): Used as a control in screening campaigns to identify novel CK2 inhibitors or to profile compound libraries.

Basic Information

Product Name	Ck2 Inhibitor 10
CAS No.	1361229-76-6
Molecular Formula	C₂₀H₂₀N₈O₂
Molecular Weight	404.43 g/mol
Synonyms	CX-4945; Silmitasertib; 5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic acid; Casein Kinase II Inhibitor CX-4945; CK2 Inhibitor CX-4945; 8-Carboxy-5-[(3-chlorophenyl)amino]benzo[c][2,6]naphthyridine
EINECS	Contact for details

Quality Control

Our Ck2 Inhibitor 10 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high chemical purity suitable for research applications. Each lot is accompanied by comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. Certificates of Analysis (COA) with detailed specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, inert environment. This compound is hygroscopic (moisture-sensitive) and light-sensitive. For long-term storage, keep desiccated under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (Mass Spectrometry)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.