Description

6-Amino-5-Fluoronicotinonitrile is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound matters for its role as a critical precursor in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, enabling the introduction of both amino and cyano functional groups. It is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of fluorinated nicotinamide derivatives and other nitrogen-containing heterocycles with potential biological activity.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the fluorine atom for enhanced efficacy and environmental stability.
• Ligand & Catalyst Development: Serves as a precursor for creating novel chelating ligands and organocatalysts used in asymmetric synthesis.
• Material Science: Employed in the research of organic electronic materials, such as fluorinated polymers and small molecules for OLEDs.
• Chemical Biology: Useful as a probe or labeling agent in biochemical research due to its reactive functional groups.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects requiring specific fluorinated pyridine scaffolds.

Basic Information

Product Name	6-Amino-5-Fluoronicotinonitrile
CAS No.	1361058-62-9
Molecular Formula	C6H4FN3
Molecular Weight	137.11 g/mol
Synonyms	5-Fluoro-6-aminonicotinonitrile; 3-Cyano-5-fluoro-6-aminopyridine; 6-Amino-5-fluoro-3-pyridinecarbonitrile; 5-Fluoro-6-amino-3-cyanopyridine; 2-Amino-5-fluoro-4-cyanopyridine; 5-Fluoro-2-amino-4-cyanopyridine; 6-Amino-5-fluoropyridine-3-carbonitrile
EINECS	Contact for details

Quality Control

Our 6-Amino-5-Fluoronicotinonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We adhere to cGMP principles where applicable to support our clients in regulated development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.