Description

Necrosulfonamide CAS NO 1360614-48-7 is a potent and selective chemical inhibitor of Mixed Lineage Kinase Domain-Like (MLKL) protein, a key executioner in the necroptosis cell death pathway. This compound is a critical research tool for elucidating the mechanisms of programmed necrosis and its role in inflammatory diseases, neurodegenerative disorders, and ischemia-reperfusion injury. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in cell biology, immunology, and drug discovery programs.

Application

• Necroptosis Research: A selective inhibitor used to dissect the role of MLKL-dependent necroptosis in various disease models.
• Inflammatory Disease Studies: Investigates the contribution of necroptosis to conditions like inflammatory bowel disease (IBD), psoriasis, and pancreatitis.
• Neurodegeneration Research: Used in studies of Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS) to understand neuronal cell death pathways.
• Ischemia-Reperfusion Injury Models: Applied in research on heart attack, stroke, and organ transplantation to assess necroptosis inhibition as a therapeutic strategy.
• Cancer Biology: Explores the complex role of necroptosis in tumor suppression, cancer cell survival, and response to therapy.
• Viral Infection Studies: Used to study how viruses modulate host cell death pathways, including necroptosis, to facilitate infection or evade immune responses.
• High-Throughput Screening (HTS): Serves as a reference compound or positive control in assays designed to discover novel necroptosis inhibitors.
• Tool Compound for Mechanism of Action (MoA) Studies: Validates the specificity of phenotypic screens and confirms MLKL involvement in observed biological effects.

Basic Information

Product Name	Necrosulfonamide
CAS No.	1360614-48-7
Molecular Formula	C₁₇H₁₅N₃O₃S
Molecular Weight	341.38 g/mol
Synonyms	MLKL Inhibitor; Necrosulfonamide (MLKL inhibitor); 5-[(4-Methylphenyl)sulfonyl]-1H-indole-2-carboxamide; 5-(p-Tolylsulfonyl)indole-2-carboxamide; 5-[(4-Methylphenyl)sulfonyl]-1H-indole-2-carboxylic acid amide; 1H-Indole-2-carboxamide, 5-[(4-methylphenyl)sulfonyl]-; Compound 1 [PMID: 22265413]; Contact for EINECS details.

Quality Control

Our Necrosulfonamide is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for sensitive biological research. Each lot undergoes comprehensive analytical characterization, including HPLC purity analysis, NMR and MS confirmation of structure, and determination of residual solvents and water content. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all test results against our stringent in-house specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.