Description

Ethyl 2,3-Difluoropyridine-4-Carboxylate is a high-purity fluorinated pyridine derivative serving as a critical building block in advanced organic synthesis. This compound is valued for its role in introducing the difluoropyridine moiety, a key structural feature that can modulate the physicochemical and biological properties of target molecules. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the preparation of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting kinase inhibitors and central nervous system (CNS) agents.
• Agrochemical Synthesis: Used in the research and development of new herbicides and fungicides, where the difluoropyridine unit can enhance metabolic stability and bioavailability.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in coordination chemistry and catalysis.
• Material Science Research: Employed in the synthesis of fluorinated organic materials and liquid crystals for electronic applications.
• Custom Synthesis and Contract Manufacturing: A valuable starting material for fine chemical manufacturers offering bespoke synthesis services.

Basic Information

Product Name	Ethyl 2,3-Difluoropyridine-4-Carboxylate
CAS No.	1359828-98-0
Molecular Formula	C8H7F2NO2
Molecular Weight	187.14 g/mol
Synonyms	Ethyl 2,3-difluoropyridine-4-carboxylate; 4-Pyridinecarboxylic acid, 2,3-difluoro-, ethyl ester; 2,3-Difluoropyridine-4-carboxylic acid ethyl ester; Ethyl 2,3-difluoroisonicotinate; 2,3-Difluoroisonicotinic acid ethyl ester; 1359828-98-0; Ethyl 2,3-difluoro-4-pyridinecarboxylate
EINECS	Contact for details

Quality Control

Our Ethyl 2,3-Difluoropyridine-4-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Typical 98.0-99.5%)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.