Description

1-Phenylcyclopropane-1-Sulfonyl Chloride is a specialized organosulfur building block of significant interest in advanced synthetic chemistry. Its core value lies in its dual functionality, serving as a versatile sulfonylation reagent and a precursor for introducing the unique, strained cyclopropane pharmacophore into target molecules. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and complex molecular scaffolds.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of new-generation pesticides and herbicides, leveraging the bioactivity of the sulfonamide and cyclopropane motifs.
• Sulfonamide Library Production: Enables high-throughput parallel synthesis for creating diverse sulfonamide-based compound libraries for biological screening.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of specialty polymers with tailored properties.
• Chemical Biology Probes: Utilized to create activity-based probes for studying enzyme function and protein interactions.
• Catalyst & Ligand Development: Acts as a precursor for synthesizing novel chiral sulfonamide ligands used in asymmetric catalysis.

Basic Information

Item	Details
Product Name	1-Phenylcyclopropane-1-Sulfonyl Chloride
CAS No.	1359655-41-6
Molecular Formula	C9H9ClO2S
Molecular Weight	216.68 g/mol
Synonyms	(1-Phenylcyclopropyl)sulfonyl chloride; 1-Phenylcyclopropanesulfonyl chloride; α-Phenylcyclopropanesulfonyl chloride; Cyclopropanesulfonyl chloride, 1-phenyl-; 1-Phenyl-1-cyclopropanesulfonyl chloride
EINECS	Contact for details

Quality Control

Our 1-Phenylcyclopropane-1-Sulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with agreed specifications. Our quality commitment supports applications in GMP and non-GMP research environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.