Description

Benzene, 2-Bromo-5-(Difluoromethoxy)-1,3-Dimethyl- is a specialized brominated and fluorinated aromatic building block of significant interest in advanced organic synthesis. Its molecular structure, featuring both bromine and difluoromethoxy substituents on a dimethylbenzene core, makes it a versatile intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by R&D and process development teams in the pharmaceutical and agrochemical industries for the development of new active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders or metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the difluoromethoxy group can enhance bioavailability and stability.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, or organic electronic materials.
• Fluorine Chemistry: A valuable substrate for further fluorination reactions and for introducing fluorine-containing motifs into complex molecular architectures.
• Cross-Coupling Reactions: The bromine atom acts as an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to form new carbon-carbon bonds.

Basic Information

Product Name	Benzene, 2-Bromo-5-(Difluoromethoxy)-1,3-Dimethyl-
CAS No.	1357627-27-0
Molecular Formula	C9H9BrF2O
Molecular Weight	251.07 g/mol
Synonyms	1,3-Dimethyl-2-bromo-5-(difluoromethoxy)benzene; 2-Bromo-1,3-dimethyl-5-(difluoromethoxy)benzene; 5-Bromo-2,4-dimethyl-1-(difluoromethoxy)benzene; 2-Bromo-5-(difluoromethoxy)-1,3-dimethylbenzene; 1-(Difluoromethoxy)-2-bromo-4,6-dimethylbenzene; Bromo-difluoromethoxy-dimethylbenzene; CAS 1357627-27-0
EINECS	Contact for details

Quality Control

Every batch of Benzene, 2-Bromo-5-(Difluoromethoxy)-1,3-Dimethyl- is produced and analyzed under a strict quality management system. We guarantee high purity and batch-to-batch consistency through advanced analytical techniques including GC, HPLC, and NMR. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to ensure it meets your specific R&D or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong alkalis and fluorides. The container should be kept tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (GC)	≥96.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.