Description

Ramipril Acyl--D-Glucuronide is a key metabolite and reference standard used in pharmaceutical research and development. This compound is critical for studying the metabolic pathways, pharmacokinetics, and bioavailability of the antihypertensive drug Ramipril. It is primarily utilized by analytical laboratories and pharmaceutical companies engaged in drug metabolism studies, bioanalytical method development, and regulatory compliance testing to ensure drug safety and efficacy.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for the quantitative and qualitative analysis of Ramipril metabolites in biological matrices.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Essential for investigating the Phase II glucuronidation metabolic pathway of Ramipril.
• Bioanalytical Method Development: Used to develop and validate sensitive HPLC-MS/MS or LC-MS methods for therapeutic drug monitoring and pharmacokinetic profiling.
• Impurity Profiling and Characterization: Acts as a marker for identifying and quantifying specific glucuronidated impurities or degradation products in active pharmaceutical ingredient (API) batches.
• Toxicology and Safety Assessment: Employed in studies to understand the distribution, excretion, and potential toxicity of Ramipril metabolites.
• Regulatory Submissions: Provides essential data for regulatory filings (e.g., FDA, EMA) requiring detailed metabolite identification and safety information.

Basic Information

Product Name	Ramipril Acyl--D-Glucuronide
CAS No.	1357570-21-8
Molecular Formula	C33H48N2O13
Molecular Weight	680.75 g/mol
Synonyms	Ramipril Acyl Glucuronide; Ramipril Glucuronide Metabolite; (2S,3aS,6aS)-1-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-3,3a,4,5,6,6a-hexahydro-2H-cyclopenta[b]pyrrole-2-carboxylic acid β-D-glucopyranosiduronic acid; Ramipril 1-O-β-Acyl Glucuronide; Ramipril Acyl-β-D-Glucuronide
EINECS	Contact for details

Quality Control

Our Ramipril Acyl--D-Glucuronide is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and analytical applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity confirmation via spectroscopic methods, and impurity profiles. We adhere to relevant industry standards for reference materials to support your critical research and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. Due to its hygroscopic (moisture-sensitive) nature, the container must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.