Description

4-Bromo-2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine is a high-value, multi-functional pyridine derivative containing both bromine and trifluoromethyl groups, making it a versatile building block for advanced chemical synthesis. This compound is specifically engineered to serve as a critical intermediate in the development of complex molecules, particularly in the pharmaceutical and agrochemical sectors. It is essential for research and development chemists, process engineers, and manufacturers seeking to introduce specific halogenated and fluorinated motifs into their target compounds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology, where the trifluoromethyl group enhances metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the pyridine core and the physicochemical influence of the bromine and fluorine substituents.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands in transition metal catalysis and organocatalysis, facilitating challenging cross-coupling and functionalization reactions.
• Material Science Research: Employed in the development of advanced organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, where fluorinated aromatic systems are prized for their electronic properties.
• Custom Synthesis and Contract Manufacturing: An important substrate for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) working on client-specific molecular scaffolds.
• Life Science Research: Utilized in academic and industrial R&D as a probe or building block for chemical biology studies and the development of molecular imaging agents.

Basic Information

Product Name	4-Bromo-2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine
CAS No.	1357476-67-5
Molecular Formula	C9H9BrF3N
Molecular Weight	268.07 g/mol
Synonyms	2-(1,1,1-Trifluoro-2-methylpropan-2-yl)-4-bromopyridine; 4-Bromo-2-(2,2,2-trifluoro-1,1-dimethylethyl)pyridine; 4-Bromo-2-(trifluoroisopropyl)pyridine; 4-Bromo-2-[(trifluoromethyl)dimethylmethyl]pyridine; Pyridine, 4-bromo-2-(1,1,1-trifluoro-2-methyl-2-propanyl)-; 4-Bromo-2-(α,α,α-trifluoro-tert-butyl)pyridine
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-(1,1,1-trifluoro-2-methylpropan-2-yl)pyridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. Handle and store in accordance with all applicable local and international regulations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.