Description

Lin28 Inhibitor Li71 is a potent and selective small molecule inhibitor of the Lin28 RNA-binding protein, a key regulator of developmental timing and cellular pluripotency. This compound is a critical research tool for investigating the Lin28/let-7 pathway, which plays a significant role in stem cell biology, tissue regeneration, and oncogenesis. It is essential for academic researchers, pharmaceutical R&D teams, and biotechnology companies focused on cancer research, regenerative medicine, and the development of novel therapeutic strategies targeting RNA-protein interactions.

Application

• Biomedical Research: Fundamental research tool for studying the molecular mechanisms of the Lin28/let-7 signaling pathway in cellular models.
• Oncology Studies: Investigation of Lin28's role in cancer stem cell maintenance, tumor progression, and metastasis in various cancer types.
• Stem Cell & Regenerative Medicine: Used to modulate pluripotency and differentiation in embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs).
• Drug Discovery & Development: Serves as a lead compound or pharmacological probe for validating Lin28 as a therapeutic target in high-throughput screening and preclinical studies.
• Biochemical Assays: Essential reagent in in vitro assays to characterize Lin28 inhibition and its downstream effects on miRNA let-7 biogenesis.

Basic Information

Product Name	Lin28 Inhibitor Li71
CAS No.	1357248-83-9
Molecular Formula	C₂₀H₂₀N₄O₃
Molecular Weight	364.40 g/mol
Synonyms	Li71; LIN28 Inhibitor Li71; 2-[[4-[(2,3-Dihydro-1,4-benzodioxin-6-yl)amino]-6-(4-morpholinyl)-1,3,5-triazin-2-yl]amino]ethanol; N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-6-morpholin-4-yl-N'-(2-hydroxyethyl)-1,3,5-triazine-2,4-diamine; LIN28 inhibitor (Li71); Li-71
EINECS	Contact for details

Quality Control

Our Lin28 Inhibitor Li71 is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity, NMR for structural confirmation, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and other critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with reference structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.