Description

n-Benzyloxycarbonyl (S)-Lisinopril-D5 is a deuterated derivative of a key pharmaceutical intermediate, specifically designed for research and development applications. This compound is crucial for internal standard use in analytical methods, enabling precise quantification and metabolic studies. It is primarily utilized by pharmaceutical researchers, analytical laboratories, and manufacturers engaged in the development and quality control of cardiovascular drugs.

Application

• Internal Standard for LC-MS/MS Analysis: Essential for accurate quantification of lisinopril and related compounds in biological matrices during pharmacokinetic and bioequivalence studies.
• Metabolic Pathway Research: Used as a stable isotope-labeled tracer to investigate the absorption, distribution, metabolism, and excretion (ADME) profiles of active pharmaceutical ingredients.
• Pharmaceutical Impurity Profiling: Aids in the identification and characterization of process-related impurities and degradation products in drug substance and product development.
• Synthetic Intermediate: Serves as a protected, labeled building block in the advanced synthesis of deuterated drug candidates for clinical research.
• Quality Control & Assurance: Employed in analytical method development and validation to ensure the specificity, accuracy, and precision of assay procedures.

Basic Information

Product Name	n-Benzyloxycarbonyl (S)-Lisinopril-D5
CAS No.	1356931-02-6
Molecular Formula	C26H37D5N3O5
Molecular Weight	~467.62 g/mol
Synonyms	(S)-1-[N2-(1-Carboxy-3-phenylpropyl)-N6-(benzyloxycarbonyl)-L-lysyl]-L-proline-D5; Z-Lisinopril-D5; Nα-Cbz-Lisinopril-D5; N6-[(Benzyloxy)carbonyl]-L-lysyl-L-proline-D5 derivative; Deuterated Cbz-Lisinopril; Lisinopril Impurity D5 (Cbz-protected); Stable Isotope Labeled Lisinopril Intermediate
EINECS	Contact for details

Quality Control

Our n-Benzyloxycarbonyl (S)-Lisinopril-D5 is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR (¹H, ¹³C) for structural confirmation and deuterium incorporation, and HPLC for purity assessment. Certificates of Analysis (COA) detailing isotopic purity, chemical purity, and specific tests are provided to ensure compliance with your research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator after opening to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Deuterium Incorporation (D-content)	≥ 98 atom % D
Purity (HPLC)	≥ 95%
Chemical Purity	≥ 97%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.