Description

2-(5-Bromopyridin-3-Yl)-1,1,1-Trifluoropropan-2-Ol CAS NO 1356483-46-9 is a high-value trifluoromethylated pyridine derivative, serving as a critical building block in modern synthetic chemistry. Its core value lies in the unique combination of a bromopyridine scaffold and a trifluoromethyl alcohol group, which enables precise structural modifications and introduces desirable physicochemical properties into target molecules. This compound is primarily sought after by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, as well as by advanced material scientists exploring functional organic molecules.

Application

• Pharmaceutical Intermediate: A key synthon for constructing active pharmaceutical ingredients (APIs), particularly in the discovery of kinase inhibitors, antiviral agents, and central nervous system (CNS) drugs.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for sophisticated ligands in transition metal catalysis and organocatalysis, enabling novel asymmetric synthesis routes.
• Material Science Research: Employed in the synthesis of advanced organic materials, such as liquid crystals, organic semiconductors, and metal-organic frameworks (MOFs), due to its electron-withdrawing and steric properties.
• Fluorine Chemistry & PET Tracer Synthesis: Acts as a versatile fluorinated building block for introducing the 18F or 19F label in Positron Emission Tomography (PET) tracer development and fluorine-based chemical biology probes.

Basic Information

Product Name	2-(5-Bromopyridin-3-Yl)-1,1,1-Trifluoropropan-2-Ol
CAS No.	1356483-46-9
Molecular Formula	C8H6BrF3NO
Molecular Weight	269.04 g/mol
Synonyms	2-(5-Bromo-3-pyridinyl)-1,1,1-trifluoro-2-propanol; 1,1,1-Trifluoro-2-(5-bromopyridin-3-yl)propan-2-ol; 5-Bromo-3-(2,2,2-trifluoro-1-hydroxy-1-methylethyl)pyridine; 3-(1-Hydroxy-2,2,2-trifluoro-1-methylethyl)-5-bromopyridine; 2-(5-Bromopyridin-3-yl)-1,1,1-trifluoropropan-2-ol; 5-Bromo-3-(1,1,1-trifluoro-2-hydroxypropan-2-yl)pyridine; 1356483-46-9; 2-(5-Bromopyridin-3-Yl)-1,1,1-Trifluoropropan-2-Ol
EINECS	Contact for details

Quality Control

Our 2-(5-Bromopyridin-3-Yl)-1,1,1-Trifluoropropan-2-Ol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical parameters. Our production adheres to cGMP (current Good Manufacturing Practice) guidelines where applicable, ensuring traceability and consistency for demanding R&D and scale-up projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from incompatible materials such as strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.