Description

1-[(2R)-N’-Boc-2-Amino-2-Cyclohexylacetyl]-n-(4’-Cyanobenzyl)-2-L-Azetidinecarboxamide-D11 is a high-purity, deuterium-labeled (D11) advanced pharmaceutical intermediate (API) used in the development of novel therapeutics. This compound is specifically designed for use in pharmacokinetic, metabolic, and bioanalytical studies, where its isotopic labeling provides a critical internal standard for mass spectrometry. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors requiring precise, stable isotope-labeled building blocks for drug discovery and development programs.

Application

• Internal Standard for LC-MS/MS: Serves as a critical quantitative reference standard in liquid chromatography-tandem mass spectrometry (LC-MS/MS) for bioanalytical method development and validation.
• Drug Metabolism and Pharmacokinetics (DMPK) Studies: Used in ADME (Absorption, Distribution, Metabolism, Excretion) studies to track and quantify the parent drug and its metabolites in biological matrices.
• Pharmaceutical Impurity Profiling: Aids in the identification and quantification of process-related impurities and degradation products during API development and quality control.
• Preclinical and Clinical Research: Enables accurate pharmacokinetic modeling in animal and human trials for candidate drugs derived from this azetidinecarboxamide scaffold.
• Synthetic Building Block: Functions as a specialized, protected intermediate for the further synthesis of complex, targeted drug molecules, particularly in peptide-mimetic and protease inhibitor research.

Basic Information

Product Name	1-[(2R)-N’-Boc-2-Amino-2-Cyclohexylacetyl]-n-(4’-Cyanobenzyl)-2-L-Azetidinecarboxamide-D11
CAS No.	1356352-32-3
Molecular Formula	C25H25D11N4O4
Molecular Weight	~475.66 g/mol
Synonyms	(2R)-2-[[(1,1-Dimethylethoxy)carbonyl]amino]-2-cyclohexyl-N-[(4-cyanophenyl)methyl]-1-(2S)-2-azetidinylcarbonyl-ethanamide-D11; Boc-(R)-Cha-Aze(CN-Bn)-NH2-D11; Deuterated Boc-Protected Azetidine Intermediate; 1-[(2R)-N-Boc-2-Amino-2-Cyclohexylacetyl]-n-(4-Cyanobenzyl)-2-L-Azetidinecarboxamide-d11; Stable Isotope Labeled Azetidinecarboxamide; D11-Labeled Pharmaceutical Intermediate; (2R)-2-((tert-Butoxycarbonyl)amino)-2-cyclohexyl-N-(4-cyanobenzyl)-1-((S)-azetidine-2-carbonyl)ethanamide-d11
EINECS	Contact for details

Quality Control

This deuterated compound is manufactured under strict GMP-like conditions to ensure batch-to-batch consistency and traceability. Quality is verified through a comprehensive suite of analytical techniques including NMR (¹H, ¹³C, 2D) for structural confirmation and deuterium incorporation, HPLC/UPLC for purity assessment, and high-resolution mass spectrometry (HRMS). A detailed Certificate of Analysis (COA) is provided with each batch, documenting purity, isotopic enrichment (D11), and all critical specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize condensation and moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (HRMS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D11)	≥ 98.0 atom % D
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.