Description

1-tert-Butyl 3-Ethyl 5,5-Difluoro-4-Oxopiperidine-1,3-Dicarboxylate is a high-value, advanced pharmaceutical intermediate characterized by its difluorinated piperidinone core structure. This compound is critical for medicinal chemistry research and development, particularly in the synthesis of novel active pharmaceutical ingredients (APIs) targeting a range of therapeutic areas. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and biotechnology industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, especially those requiring a fluorinated heterocyclic scaffold for enhanced metabolic stability and bioavailability.
• Medicinal Chemistry Research: Used extensively in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Process Chemistry Development: Serves as a starting material or intermediate in the scale-up and route development for new pharmaceutical manufacturing processes.
• Protease Inhibitor Synthesis: Its structure is applicable in the development of inhibitors for various proteases, a common target class in drug discovery.
• Agrochemical Research: Potential use as an intermediate in the development of novel, fluorinated agrochemicals with improved properties.
• Chemical Biology Probes: Can be utilized to create tool compounds for studying biological pathways and target engagement.

Basic Information

Product Name	1-tert-Butyl 3-Ethyl 5,5-Difluoro-4-Oxopiperidine-1,3-Dicarboxylate
CAS No.	1356338-74-3
Molecular Formula	C14H21F2NO5
Molecular Weight	321.32 g/mol
Synonyms	1-(tert-Butyl) 3-ethyl 5,5-difluoro-4-oxopiperidine-1,3-dicarboxylate; 5,5-Difluoro-4-oxo-1-piperidinecarboxylic acid 1-(1,1-dimethylethyl) 3-ethyl ester; tert-Butyl 3-ethoxycarbonyl-5,5-difluoro-4-oxopiperidine-1-carboxylate; 1-Boc-3-ethyl 5,5-difluoro-4-oxopiperidine-1,3-dicarboxylate; 5,5-Difluoro-1-Boc-4-oxopiperidine-3-carboxylic acid ethyl ester; Ethyl 1-Boc-5,5-difluoro-4-oxopiperidine-3-carboxylate; 1-N-Boc-3-ethyl 5,5-difluoro-4-oxopiperidine-1,3-dicarboxylate
EINECS	Contact for details

Quality Control

Our 1-tert-Butyl 3-Ethyl 5,5-Difluoro-4-Oxopiperidine-1,3-Dicarboxylate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent moisture uptake and potential degradation. Recommended storage temperature: 2-8°C for prolonged stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.