Description

1-(4-Chloropyridin-2-Yl)-2,2,2-Trifluoroethanone is a high-value trifluoromethyl ketone building block featuring a chloropyridine scaffold. This compound matters for its role as a critical intermediate in the synthesis of advanced agrochemicals and active pharmaceutical ingredients (APIs), where the trifluoromethyl group is prized for enhancing metabolic stability and lipophilicity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing novel heterocyclic compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the chloropyridine moiety.
• Material Science Research: Serves as a precursor for specialty chemicals and functional materials, including liquid crystals and organic electronic components.
• Chemical Biology Probes: Employed in the creation of molecular probes and inhibitors for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects and scale-up manufacturing under cGMP conditions.

Basic Information

Item	Details
Product Name	1-(4-Chloropyridin-2-Yl)-2,2,2-Trifluoroethanone
CAS No.	1356086-78-6
Molecular Formula	C7H3ClF3NO
Molecular Weight	209.55 g/mol
Synonyms	2,2,2-Trifluoro-1-(4-chloro-2-pyridinyl)ethanone; 1-(4-Chloro-2-pyridinyl)-2,2,2-trifluoroethanone; 4-Chloro-2-(trifluoroacetyl)pyridine; 2-(Trifluoroacetyl)-4-chloropyridine; 4-Chloro-α,α,α-trifluoro-2-pyridinylmethanone; 1356086-78-6; 4-Chloro-2-pyridyl trifluoromethyl ketone
EINECS	Contact for details

Quality Control

Our 1-(4-Chloropyridin-2-Yl)-2,2,2-Trifluoroethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for demanding R&D and scale-up applications. Certificates of Analysis (COA) with full traceability are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.