Description

3-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinonitrile is a high-value, multi-functional boronic ester building block designed for advanced organic synthesis. This compound is critical for enabling efficient cross-coupling reactions, allowing for the precise construction of complex molecular architectures. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries to accelerate the discovery and production of novel active ingredients.

Application

This versatile boronic ester is a key intermediate in modern synthetic chemistry, enabling a wide range of transformations.

• Suzuki-Miyaura Cross-Coupling Reactions: The primary application is as a coupling partner with aryl/heteroaryl halides for the efficient formation of carbon-carbon bonds, a cornerstone reaction in medicinal chemistry.
• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing fluorinated pyridine cores.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific fluorinated heterocyclic structures.
• Ligand and Catalyst Development: The nitrile and fluorine substituents make it a valuable precursor for creating specialized ligands used in catalysis and coordination chemistry.
• Materials Science Research: Employed in the synthesis of organic electronic materials, such as those used in OLEDs or semiconductors, where fluorination tunes electronic properties.
• Chemical Biology Probes: Useful for synthesizing tagged molecules or probes for studying biological systems and target engagement.

Basic Information

Product Name	3-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinonitrile
CAS No.	1356066-65-3
Molecular Formula	C₁₃H₁₆BFN₂O₂
Molecular Weight	262.09 g/mol
Synonyms	3-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinonitrile; 2-Cyano-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-fluoropyridine; 3-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinecarbonitrile; 3-Fluoro-5-(pinacolatoboron)picolinonitrile; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-fluoropicolinonitrile; Pinacol 3-Cyano-5-fluoropyridine-2-boronate
EINECS	Contact for details

Quality Control

Our production of 3-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinonitrile adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for your critical synthetic steps. All materials are characterized by modern analytical techniques including NMR, HPLC, and LC-MS. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and when dispensing to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.