Description

Methyl 6-(Difluoromethyl)Nicotinate is a high-purity, advanced pharmaceutical intermediate and versatile chemical building block. Its core value lies in the unique difluoromethyl-substituted pyridine structure, which is critical for modulating the physicochemical and metabolic properties of target molecules in drug discovery. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially in kinase inhibitor and antiviral drug candidates.
• Agrochemical Synthesis: Used in the research and production of advanced crop protection agents, including herbicides and fungicides.
• Chemical Building Block: Serves as a versatile precursor in organic synthesis for introducing the difluoromethylpyridine moiety into complex molecules.
• Material Science Research: Employed in the development of specialty chemicals and functional materials, such as ligands for catalysis.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations engaged in custom synthesis and process development for client projects.

Basic Information

Product Name	Methyl 6-(Difluoromethyl)Nicotinate
CAS No.	1355729-43-9
Molecular Formula	C8H7F2NO2
Molecular Weight	187.14 g/mol
Synonyms	Methyl 6-(difluoromethyl)pyridine-3-carboxylate; 3-Pyridinecarboxylic acid, 6-(difluoromethyl)-, methyl ester; 6-(Difluoromethyl)nicotinic acid methyl ester; Methyl 6-difluoromethylnicotinate; Nicotinic acid, 6-(difluoromethyl)-, methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 6-(Difluoromethyl)Nicotinate is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with each shipment, confirming compliance with customer specifications and supporting regulatory requirements for advanced research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (typically 15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed in a dry environment.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.