Description

3-Methyl-Isothiazole-5-Sulfonyl Chloride is a high-purity, reactive sulfonyl chloride derivative essential for advanced chemical synthesis. This compound serves as a critical building block for introducing the 3-methylisothiazole-5-sulfonyl moiety, a valuable functional group in medicinal chemistry and materials science. It is primarily sought after by research institutions and industrial manufacturers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for sulfonamide-based drugs.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science Research: Employed to create functional polymers and advanced materials with specific surface properties.
• Chemical Biology Probes: Acts as a reactive handle for labeling and modifying biomolecules in proteomics and diagnostic assay development.
• Ligand Synthesis for Catalysis: Building block for constructing specialized ligands used in homogeneous catalysis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of client-specific novel chemical entities (NCEs).

Basic Information

Product Name	3-Methyl-Isothiazole-5-Sulfonyl Chloride
CAS No.	1355334-86-9
Molecular Formula	C4H4ClNO2S2
Molecular Weight	197.67 g/mol
Synonyms	3-Methyl-1,2-thiazole-5-sulfonyl chloride; 5-(Chlorosulfonyl)-3-methyl-1,2-thiazole; 3-Methylisothiazole-5-sulfonyl chloride; 3-Methyl-5-isothiazolesulfonyl chloride; 3-Methyl-δ2-isothiazoline-5-sulfonyl chloride; 3-Methyl-1,2-thiazol-5-ylsulfonyl chloride
EINECS	Contact for details

Quality Control

Every batch of 3-Methyl-Isothiazole-5-Sulfonyl Chloride is manufactured and tested under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and other relevant methods is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and reactive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.