Description

Mutant Idh1-In-1 CAS NO 1355326-21-4 is a potent and selective small-molecule inhibitor of the mutant isocitrate dehydrogenase 1 (IDH1) enzyme. This compound is of significant value in oncology research, specifically targeting the altered metabolic pathways found in certain cancers like gliomas and acute myeloid leukemia (AML). It is an essential research-grade chemical for pharmaceutical R&D teams, academic institutions, and biotechnology companies focused on developing novel targeted cancer therapies and understanding tumor metabolism.

Application

• Oncology Research & Drug Discovery: A key tool compound for studying the biological role and inhibition of mutant IDH1 in cellular and animal models of cancer.
• Biochemical Assay Development: Used as a reference standard in high-throughput screening (HTS) campaigns to identify new IDH1 inhibitor scaffolds.
• Mechanism of Action Studies: Enables research into the downstream effects of mutant IDH1 inhibition, including 2-hydroxyglutarate (2-HG) production and associated epigenetic changes.
• Preclinical Pharmacology: Supports pharmacokinetic (PK), pharmacodynamic (PD), and efficacy studies in the development of targeted cancer therapeutics.
• Academic Research: Facilitates fundamental research in cancer metabolism and cellular differentiation pathways influenced by IDH1 mutations.

Basic Information

Product Name	Mutant Idh1-In-1
CAS No.	1355326-21-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Mutant IDH1 Inhibitor; IDH1 Mutant Inhibitor; AGI-5198 analog; Isocitrate Dehydrogenase 1 (IDH1) Mutant Inhibitor; (R)-Enantiomer of AGI-5198 (related); Research Compound 1355326-21-4; Small Molecule IDH1 Inhibitor; Oncology Research Inhibitor
EINECS	Contact for details

Quality Control

Our Mutant Idh1-In-1 is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical testing, including HPLC purity analysis, NMR structural confirmation, and mass spectrometry (MS) to verify identity and potency. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all relevant specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, moisture-free environment. This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a controlled, dry environment to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.