Description

(R)-2-(tert-Butoxycarbonylamino)-3,3,3-Trifluoropropanoic Acid is a high-value, non-natural amino acid derivative featuring a chiral center and a trifluoromethyl group. This compound serves as a critical chiral building block in modern organic synthesis, prized for its ability to impart metabolic stability and modulate physicochemical properties in target molecules. It is primarily utilized by pharmaceutical R&D and process chemistry teams for the development of novel active pharmaceutical ingredients (APIs), particularly in the areas of peptidomimetics and small molecule drugs.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug candidates, especially those targeting central nervous system (CNS) and metabolic diseases.
• Peptidomimetic Research: Used to incorporate a trifluoromethylated amino acid residue into peptide backbones to enhance stability, lipophilicity, and binding affinity.
• Agrochemical Synthesis: Serves as a building block for advanced crop protection agents, leveraging the fluorine atom's ability to improve bioactivity and environmental persistence.
• Ligand and Catalyst Development: Employed in the preparation of chiral ligands and organocatalysts for asymmetric synthesis.
• Material Science Precursor: Potential use in the synthesis of specialty polymers and advanced materials with unique surface properties.
• Fluorine Chemistry Studies: A valuable reference compound for investigating the stereoelectronic effects of the trifluoromethyl group in chemical reactions.

Basic Information

Product Name	(R)-2-(tert-Butoxycarbonylamino)-3,3,3-Trifluoropropanoic Acid
CAS No.	1354225-89-0
Molecular Formula	C8H12F3NO4
Molecular Weight	243.18 g/mol
Synonyms	Boc-(R)-3,3,3-Trifluoroalanine; (R)-2-((tert-Butoxycarbonyl)amino)-3,3,3-trifluoropropanoic Acid; (R)-N-Boc-3,3,3-Trifluoroalanine; (R)-3,3,3-Trifluoroalanine N-Boc Derivative; (R)-Boc-Aib(CF3)-OH; (R)-Boc-NH-CH(CF3)-COOH; (R)-N-(tert-Butoxycarbonyl)-3,3,3-trifluoroalanine; (2R)-2-[[(2-Methylpropan-2-yl)oxycarbonyl]amino]-3,3,3-trifluoropropanoic Acid
EINECS	Contact for details

Quality Control

Our production of (R)-2-(tert-Butoxycarbonylamino)-3,3,3-Trifluoropropanoic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chemical purity. All materials are subjected to comprehensive analytical testing, including chiral HPLC to confirm enantiomeric excess (ee) and NMR for structural verification. A Certificate of Analysis (COA) detailing purity, assay, chiral purity, and impurity profiles is provided with each shipment. We support development under cGMP guidelines for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere or in a controlled humidity environment to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.