Description

n-Acetyl-S-[[[4-(Methylsulfinyl)Butyl-D8]Amino]Thioxomethyl]- is a high-purity, deuterated biochemical reagent designed for advanced research and development. This compound is critical for applications requiring precise isotopic labeling, such as in mass spectrometry-based proteomics and metabolic pathway tracing. It is primarily utilized by pharmaceutical R&D teams, analytical laboratories, and academic researchers focused on biomarker discovery and drug metabolism studies.

Application

• Isotopic Labeling Agent: Used as a deuterium-labeled internal standard for the accurate quantification of related metabolites or proteins via Liquid Chromatography-Mass Spectrometry (LC-MS/MS).
• Proteomics Research: Serves as a key reagent in chemical proteomics for profiling enzyme activity or studying post-translational modifications.
• Drug Metabolism and Pharmacokinetics (DMPK): Employed in the synthesis of labeled drug analogs to track absorption, distribution, metabolism, and excretion (ADME) in preclinical studies.
• Biomarker Discovery: Facilitates the identification and validation of disease biomarkers through stable isotope dilution techniques.
• Chemical Biology Probes: Used to develop activity-based probes for investigating the function of cysteine proteases and other thiol-dependent enzymes.
• Reference Standard: Provides a certified reference material for analytical method development and validation in regulatory-compliant laboratories.

Basic Information

Product Name	n-Acetyl-S-[[[4-(Methylsulfinyl)Butyl-D8]Amino]Thioxomethyl]-
CAS No.	1354064-85-9
Molecular Formula	C8H7D8N2O2S2
Molecular Weight	Contact for details
Synonyms	N-Acetyl-S-((4-(Methylsulfinyl)butyl-D8)carbamothioyl)cysteine; Deuterated Acetyl-S-(4-(Methylsulfinyl)butyl)isothiourea Derivative; [D8]-Labeled MSBT Probe; 4-(Methylsulfinyl)butyl-D8 isothiourea acetate; S-[[[4-(Methylsulfinyl)Butyl-D8]Amino]Thioxomethyl]-N-acetylcysteine; Activity-Based Proteomic Probe (Deuterated); Deuterium-Labeled Cysteine Protease Probe
EINECS	Contact for details

Quality Control

Every batch of n-Acetyl-S-[[[4-(Methylsulfinyl)Butyl-D8]Amino]Thioxomethyl]- is manufactured under strict quality management systems. Our products undergo rigorous quality testing, including NMR and LC-MS, to ensure isotopic purity, chemical purity, and structural identity conform to the highest standards for research use. Certificates of Analysis (COA) with detailed batch-specific data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. Allow the sealed vial to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Isotopic Purity (D-content)	≥ 98 atom % D
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.