Description

1-Bromo-2-Cyclopropyl-4-(Trifluoromethyl)Benzene is a high-value halogenated aromatic building block, distinguished by its unique cyclopropyl and trifluoromethyl substituents. This compound is essential for advanced organic synthesis, offering a versatile scaffold for constructing complex molecules with tailored electronic and steric properties. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for applications in drug discovery, material science, and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Fluorine Chemistry Building Block: The trifluoromethyl group provides a source of fluorine for further derivatization in medicinal chemistry to improve lipophilicity and bioavailability.
• Chemical Biology Probes: Utilized in the design and synthesis of molecular probes for studying enzyme mechanisms and protein-ligand interactions.

Basic Information

Item	Detail
Product Name	1-Bromo-2-Cyclopropyl-4-(Trifluoromethyl)Benzene
CAS No.	1353857-12-1
Molecular Formula	C10H8BrF3
Molecular Weight	265.07 g/mol
Synonyms	2-Bromo-1-Cyclopropyl-4-(Trifluoromethyl)Benzene; 1-Bromo-2-Cyclopropyl-α,α,α-trifluoro-p-xylene; 4-Bromo-3-Cyclopropylbenzotrifluoride; (2-Bromo-4-(trifluoromethyl)phenyl)cyclopropane; 2-Cyclopropyl-4-(trifluoromethyl)bromobenzene; 1-Bromo-2-cyclopropyl-4-(trifluoromethyl)benzene; 1353857-12-1
EINECS	Contact for details

Quality Control

Our 1-Bromo-2-Cyclopropyl-4-(Trifluoromethyl)Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with every shipment to guarantee traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible materials such as strong bases and oxidizing agents. The container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.