Description

2-Bromo-1-Cyclopropyl-4-Fluorobenzene is a high-value, multi-functional halogenated aromatic building block. This compound is specifically engineered to serve as a critical intermediate in advanced organic synthesis, offering a unique combination of a bromo substituent for cross-coupling reactions and a cyclopropyl group for introducing conformational rigidity. It is primarily utilized by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and anti-infective agents.
• Agrochemical Synthesis: Used in the development of new-generation herbicides, fungicides, and insecticides, where the cyclopropyl moiety can enhance biological activity and stability.
• Material Science Research: Serves as a building block for creating specialized organic ligands, liquid crystals, and advanced polymers with tailored electronic properties.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and Buchwald-Hartwig amination reactions to form complex biaryl and heterocyclic systems.
• Chemical Biology Probes: Utilized in medicinal chemistry for structure-activity relationship (SAR) studies and the development of molecular probes.

Basic Information

Product Name	2-Bromo-1-Cyclopropyl-4-Fluorobenzene
CAS No.	1353855-60-3
Molecular Formula	C9H8BrF
Molecular Weight	215.06 g/mol
Synonyms	1-Bromo-2-cyclopropyl-5-fluorobenzene; 2-Bromo-1-cyclopropyl-4-fluorobenzene; 4-Fluoro-2-bromo-1-cyclopropylbenzene; Benzene, 2-bromo-1-cyclopropyl-4-fluoro-; (2-Bromo-4-fluorophenyl)cyclopropane
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-1-Cyclopropyl-4-Fluorobenzene is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure consistency and high purity. Our standard grade meets specifications suitable for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, GC, and NMR is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon to maximize stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.