Description

Methyl 2,3-Difluoroisonicotinate CAS NO 1353102-03-0 is a high-purity fluorinated pyridine derivative, a crucial building block in advanced organic synthesis. Its value lies in the strategic placement of fluorine atoms, which are essential for modulating the biological activity, metabolic stability, and physicochemical properties of target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of fluorinated drug candidates, particularly in kinase inhibitor and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of next-generation herbicides and pesticides, where fluorine incorporation enhances efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands and catalysts used in cross-coupling and other metal-mediated reactions.
• Material Science Research: Employed in the synthesis of fluorinated organic electronic materials and liquid crystals.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis projects requiring specific fluorinated isonicotinate scaffolds.
• Academic & Institutional Research: Used in universities and research institutes for methodological studies in fluorination chemistry and heterocyclic compound synthesis.

Basic Information

Item	Details
Product Name	Methyl 2,3-Difluoroisonicotinate
CAS No.	1353102-03-0
Molecular Formula	C7H5F2NO2
Molecular Weight	173.12 g/mol
Synonyms	2,3-Difluoropyridine-4-carboxylic acid methyl ester; Methyl 2,3-difluoro-4-pyridinecarboxylate; 2,3-Difluoroisonicotinic acid methyl ester; 4-(Methoxycarbonyl)-2,3-difluoropyridine; 2,3-Difluoro-4-(methoxycarbonyl)pyridine; Methyl 2,3-difluoropyridine-4-carboxylate
EINECS	Contact for details

Quality Control

Every batch of Methyl 2,3-Difluoroisonicotinate is produced under strict quality management protocols. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. Our standard grade typically meets a purity specification of ≥97% (HPLC), with specifications for individual impurities available. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 97.0%
Purity (HPLC Area%)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.