Description

Bromoacetamido-Peg2- Nhs Ester is a heterobifunctional crosslinking reagent featuring an amine-reactive NHS ester and a thiol-reactive bromoacetamide group, connected by a hydrophilic polyethylene glycol (PEG) spacer. This compound is critical for creating stable, site-specific conjugates in aqueous environments, particularly for sensitive biomolecules. It is primarily utilized by researchers and manufacturers in the fields of bioconjugation, antibody-drug conjugate (ADC) development, and advanced diagnostics.

Application

• Antibody-Drug Conjugate (ADC) Linker: A key reagent for constructing cleavable or non-cleavable linkers between cytotoxic payloads and monoclonal antibodies.
• PEGylated Protein/Peptide Modification: Enables the site-specific PEGylation of cysteine residues to improve pharmacokinetic properties like solubility and circulation half-life.
• Surface Functionalization: Used to modify gold nanoparticles, biosensors, or chromatography resins with thiol-reactive groups for subsequent biomolecule immobilization.
• Fluorescent Probe & Diagnostic Reagent Synthesis: Facilitates the conjugation of dyes, haptens, or other reporter molecules to proteins, antibodies, or oligonucleotides via a stable thioether bond.
• Biomaterial & Hydrogel Crosslinking: Serves as a crosslinker for creating biocompatible networks in tissue engineering and drug delivery systems.
• Stable Cell-Permeable Conjugate Preparation: The bromoacetamide group forms stable conjugates with free thiols, useful for creating cell-penetrating peptide-drug conjugates.

Basic Information

Product Name	Bromoacetamido-Peg2- Nhs Ester
CAS No.	1353011-78-5
Molecular Formula	C₁₅H₂₃BrN₂O₈
Molecular Weight	439.26 g/mol
Synonyms	N-(Bromoacetamido-PEG2)-NHS Ester; Bromoacetyl-PEG2-NHS Ester; 2,5-Dioxopyrrolidin-1-yl 3-[2-[2-(2-bromoacetamido)ethoxy]ethoxy]propanoate; Bromoacetamido-PEG2-NHS; Bromoacetamido-dPEG®2-NHS ester; Bromoacetamide-PEG2-NHS; NHS-PEG2-Bromoacetamide; Bromoacetamido-triethyleneglycol NHS ester
EINECS	Contact for details

Quality Control

Our Bromoacetamido-Peg2- Nhs Ester is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for critical research and development applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and functional group integrity. We support compliance with relevant standards for research and pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This product is hygroscopic (moisture-sensitive) and light-sensitive (store away from light). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (H-NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMF, DMSO, acetonitrile

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.