Description

3-Fluoro-5-(Trifluoromethyl)Benzaldehyde is a versatile fluorinated aromatic aldehyde building block. This compound is valued for its unique electronic properties imparted by the fluorine and trifluoromethyl substituents, which are critical for modulating the reactivity, lipophilicity, and metabolic stability of target molecules. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting CNS disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the fluorine atoms enhance biological activity and environmental stability.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals and organic light-emitting diode (OLED) materials, contributing to improved electronic properties.
• Functional Polymer Monomer: Employed in the synthesis of specialty polymers with tailored surface properties, chemical resistance, and optical characteristics.
• Cross-Coupling Reactions: The aldehyde and halogen groups make it a suitable substrate for Suzuki, Sonogashira, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Chemical Research & Development: A valuable reagent in academic and industrial R&D for exploring new fluorination chemistry and creating compound libraries for screening.

Basic Information

Product Name	3-Fluoro-5-(Trifluoromethyl)Benzaldehyde
CAS No.	1352999-98-4
Molecular Formula	C8H4F4O
Molecular Weight	192.11 g/mol
Synonyms	5-(Trifluoromethyl)-3-fluorobenzaldehyde; 3-Fluoro-5-(trifluoromethyl)benzaldehyde; 3-Fluoro-α,α,α-trifluoro-m-tolualdehyde; m-Trifluoromethyl-3-fluorobenzaldehyde; Benzaldehyde, 3-fluoro-5-(trifluoromethyl)-; 1352999-98-4
EINECS	Contact for details

Quality Control

Every batch of 3-Fluoro-5-(Trifluoromethyl)Benzaldehyde is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). This material is easily oxidized and should be handled under an inert atmosphere for long-term storage or after opening to maintain purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Standard Grade)
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.