Description

Igf-1R Inhibitor CAS NO 1352873-82-5 is a potent and selective small molecule inhibitor of the Insulin-like Growth Factor 1 Receptor (IGF-1R), a key target in oncology research. This compound is crucial for investigating signaling pathways involved in cell proliferation, survival, and tumor growth inhibition. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on developing novel cancer therapeutics.

Application

• Oncology Research & Drug Discovery: A critical tool for studying the role of IGF-1R signaling in various cancers, including breast, lung, and colorectal.
• Biochemical Assay Development: Used as a reference standard in high-throughput screening (HTS) and enzymatic assays to identify and characterize new drug candidates.
• Mechanism of Action (MoA) Studies: Enables researchers to elucidate downstream effects of IGF-1R inhibition on cellular pathways like PI3K/AKT and MAPK/ERK.
• Preclinical In Vitro & In Vivo Models: Employed in cell culture and animal studies to evaluate the efficacy and pharmacokinetics of anti-cancer strategies.
• Signal Transduction Research: Serves as a specific probe to dissect complex receptor tyrosine kinase (RTK) networks and their crosstalk.
• Combination Therapy Research: Investigated for potential synergistic effects when used alongside chemotherapy, radiotherapy, or other targeted agents.

Basic Information

Product Name	Igf-1R Inhibitor
CAS No.	1352873-82-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	IGF-1R Inhibitor; IGF1R Inhibitor; Insulin-like growth factor 1 receptor inhibitor; IGF-1R tyrosine kinase inhibitor; (S)-N-(4-(4-(Dimethylamino)piperidine-1-carbonyl)phenyl)-3-(4-fluorophenyl)-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridine-5-carboxamide; BMS-754807 (common research code); CAS 1352873-82-5
EINECS	Contact for details

Quality Control

Our Igf-1R Inhibitor is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.