Description

2-Fluoropyrimidine-5-Boronic Acid Pinacol Ester is a high-value, organoboron building block crucial for modern synthetic chemistry. This compound matters because it enables efficient carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules. Pharmaceutical, agrochemical, and advanced materials researchers need it for the streamlined synthesis of fluorinated pyrimidine derivatives, which are key scaffolds in drug discovery and development.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates containing fluoropyrimidine motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and pesticides with improved efficacy and selectivity.
• Material Science Research: Employed in the creation of organic electronic materials, such as OLEDs and semiconductors, where fluorinated heterocycles enhance performance.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester reagent for palladium-catalyzed coupling reactions to form biaryl and heterobiaryl structures.
• Medicinal Chemistry Library Development: Facilitates the rapid, parallel synthesis of diverse compound libraries for high-throughput screening in drug discovery programs.
• Chemical Biology Probes: Used to create tagged or labeled molecules for studying biological processes and target engagement.

Basic Information

Product Name	2-Fluoropyrimidine-5-Boronic Acid Pinacol Ester
CAS No.	1352796-65-6
Molecular Formula	C10H14BFN2O2
Molecular Weight	224.04 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-fluoropyrimidine; 2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrimidine; 2-Fluoropyrimidin-5-ylboronic Acid Pinacol Ester; (2-Fluoropyrimidin-5-yl)boronic Acid Pinacol Ester; 2-Fluoro-5-pyrimidineboronic Acid Pinacol Ester; 2-Fluoropyrimidine-5-boronic Acid, Pinacol Ester; 2-Fluoropyrimidine-5-boronic Acid Pinacol Ester CAS 1352796-65-6
EINECS	Contact for details

Quality Control

Our 2-Fluoropyrimidine-5-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistency. Certificates of Analysis (COA) with detailed specifications are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.