Description

3-Chloro-4-Fluoro-5-Nitrotoluene is a high-purity, multi-functional aromatic intermediate of significant importance in advanced organic synthesis. Its unique halogenated and nitrated structure makes it a valuable building block for constructing complex molecules with tailored properties. This compound is primarily sought after by R&D chemists and process engineers in the pharmaceutical and agrochemical sectors for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing fluorinated and chlorinated aromatic rings.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where its substitution pattern can influence bioactivity.
• Material Science Research: Serves as a monomer or functionalization agent in the development of specialty polymers, liquid crystals, and electronic materials.
• Dye & Pigment Intermediate: Employed in the synthesis of complex, high-performance dyes and organic pigments due to its nitro and halogen functional groups.
• Cross-Coupling Reactions: An excellent substrate for various palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to create biaryl structures.
• Organic Synthesis Building Block: Provides a versatile scaffold for further chemical transformations, including reduction of the nitro group or nucleophilic aromatic substitution.

Basic Information

Item	Details
Product Name	3-Chloro-4-Fluoro-5-Nitrotoluene
CAS No.	1352457-29-4
Molecular Formula	C7H5ClFNO2
Molecular Weight	189.57 g/mol
Synonyms	1-Chloro-2-fluoro-3-methyl-4-nitrobenzene; 3-Chloro-4-fluoro-5-nitrotoluene; 2-Fluoro-3-methyl-1-chloro-4-nitrobenzene; 5-Nitro-3-chloro-4-fluorotoluene; Toluene, 3-chloro-4-fluoro-5-nitro-; 3-Chloro-4-fluoro-5-nitro-1-methylbenzene; 4-Fluoro-3-chloro-5-nitrotoluene
EINECS	Contact for details

Quality Control

Our 3-Chloro-4-Fluoro-5-Nitrotoluene is manufactured under a strict quality management system. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistent lot-to-lot performance. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The compound is light-sensitive and should be stored away from direct light exposure.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.