Description

1-Bromo-4-(2,2-Dichloro-3,3-Difluorocyclobutyl)Benzene is a high-value, multi-functional halogenated aromatic building block. This compound is engineered to provide a unique combination of a reactive bromoarene site and a sterically defined, halogenated cyclobutyl moiety, making it a critical intermediate for advanced synthesis. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecular architectures, such as novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of new drug candidates, particularly in constructing bioactive scaffolds with enhanced metabolic stability.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and insecticides, where the halogenated cyclobutane ring can impart unique biological activity and environmental persistence profiles.
• Material Science Research: Acts as a precursor for advanced polymers, liquid crystals, or organic electronic materials due to its rigid, halogen-substituted structure.
• Cross-Coupling Reactions: The bromine atom is an excellent handle for palladium-catalyzed reactions (e.g., Suzuki, Heck, Sonogashira) to create complex biaryl systems.
• Fluorine Chemistry Building Block: The difluorocyclobutyl group is valuable for introducing fluorine atoms into target molecules to modulate lipophilicity, bioavailability, and binding affinity.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for client-specific projects requiring specialized halogenated intermediates.

Basic Information

Product Name	1-Bromo-4-(2,2-Dichloro-3,3-Difluorocyclobutyl)Benzene
CAS No.	1352318-34-3
Molecular Formula	C10H7BrCl2F2
Molecular Weight	328.87 g/mol
Synonyms	4-Bromo-1-(2,2-dichloro-3,3-difluorocyclobutyl)benzene; p-Bromo(2,2-dichloro-3,3-difluorocyclobutyl)benzene; 1-(4-Bromophenyl)-2,2-dichloro-3,3-difluorocyclobutane; (2,2-Dichloro-3,3-difluorocyclobutyl)benzene, 4-bromo-; BCDFB (abbreviation); Benzene, 1-bromo-4-(2,2-dichloro-3,3-difluorocyclobutyl)-
EINECS	Contact for details

Quality Control

Every batch of 1-Bromo-4-(2,2-Dichloro-3,3-Difluorocyclobutyl)Benzene is manufactured under strict quality management systems. We provide comprehensive analytical documentation to ensure traceability and consistency for your critical R&D and scale-up processes. A detailed Certificate of Analysis (COA) confirming identity, purity, and impurity profiles by HPLC, GC, NMR, and IR is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure (¹H NMR, ¹³C NMR, ¹⁹F NMR)
Purity (HPLC)	≥ 97.0% (Area %)
Related Substances (HPLC)	Total impurities ≤ 3.0%
Melting Point	Contact for details
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.