Description

(R)-3-Methyl-4-(6-(1-((R)-S-Methylsulfonimidoyl)Cyclopropyl)-2-(1-Tosyl-1H-Pyrrolo[2,3-B]Pyridin-4-Yl)Pyrimidin-4-Yl)Morpholine is a high-purity, advanced pharmaceutical intermediate characterized by its complex chiral structure. This compound is of critical importance for the research and development of targeted therapeutic agents, particularly in oncology and other disease areas involving specific enzymatic pathways. It is primarily required by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel, high-value active pharmaceutical ingredients (APIs).
• Oncology Drug Discovery: Used in research programs targeting specific kinases or protein-protein interactions for cancer therapeutics.
• Preclinical & Clinical Development: Serves as a critical material for producing compounds for pharmacological testing, toxicology studies, and early-phase clinical trials.
• Process Chemistry & Scale-Up: Employed by process chemists to develop and optimize scalable synthetic routes for candidate drugs.
• Asymmetric Synthesis: Utilized in reactions requiring high stereochemical control due to its defined chiral centers.
• Biochemical Research: Acts as a tool compound or a precursor for probes in biochemical and cellular assays to study disease mechanisms.

Basic Information

Item	Details
Product Name	(R)-3-Methyl-4-(6-(1-((R)-S-Methylsulfonimidoyl)Cyclopropyl)-2-(1-Tosyl-1H-Pyrrolo[2,3-B]Pyridin-4-Yl)Pyrimidin-4-Yl)Morpholine
CAS No.	1352232-89-3
Molecular Formula	C28H32N6O4S2
Molecular Weight	580.72 g/mol
Synonyms	(R)-3-Methyl-4-[6-[1-[(R)-S-Methylsulfonimidoyl]cyclopropyl]-2-(1-tosylpyrrolo[2,3-b]pyridin-4-yl)pyrimidin-4-yl]morpholine; 1352232-89-3; (R,R)-Enantiomer of a Morpholine-Pyrimidine Sulfoximine Intermediate; 4-(6-(1-((R)-Methylsulfonimidoyl)cyclopropyl)-2-(1-tosyl-1H-pyrrolo[2,3-b]pyridin-4-yl)pyrimidin-4-yl)-3-methylmorpholine; Sulfoximine-based Kinase Inhibitor Intermediate; Chiral Sulfilimine Derivative
EINECS	Contact for details

Quality Control

Every batch of (R)-3-Methyl-4-(6-(1-((R)-S-Methylsulfonimidoyl)Cyclopropyl)-2-(1-Tosyl-1H-Pyrrolo[2,3-B]Pyridin-4-Yl)Pyrimidin-4-Yl)Morpholine is produced and tested under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and chiral integrity, meeting the stringent requirements for pharmaceutical development. Certificates of Analysis (COA) with detailed HPLC, NMR, and chiral purity data are available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening the container to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.