Description

Btk Kinase Inhibitor CAS NO 1351636-18-4 is a potent and selective small molecule inhibitor targeting Bruton's tyrosine kinase (Btk), a key enzyme in the B-cell receptor signaling pathway. This compound is a critical research tool for investigating B-cell malignancies, autoimmune disorders, and inflammatory diseases. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in drug discovery and preclinical studies.

Application

• Biomedical Research: A key reagent for studying B-cell signaling pathways, immune cell activation, and the role of Btk in disease pathology.
• Drug Discovery & Development: Serves as a reference standard and a lead compound in the development of novel therapeutics for B-cell cancers like chronic lymphocytic leukemia (CLL) and mantle cell lymphoma (MCL).
• Autoimmune Disease Research: Used in in vitro and in vivo models to explore treatments for conditions such as rheumatoid arthritis, lupus, and multiple sclerosis.
• Pharmacology & Toxicology Studies: Employed to assess efficacy, potency (IC50), selectivity, and mechanism of action in various cellular and biochemical assays.
• Chemical Biology: Useful for probing kinase function and for the development of associated diagnostic and screening tools.

Basic Information

Product Name	Btk Kinase Inhibitor
CAS No.	1351636-18-4
Molecular Formula	C21H23N5O3
Molecular Weight	393.44 g/mol
Synonyms	BGB-3111; Zanubrutinib; (S)-7-(1-Acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine-6-carboxamide; Brukinsa (Trade Name); BTK Inhibitor BGB-3111; 4-[2-(4-Phenoxyphenyl)-6-carbamoyl-4,5-dihydro-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-1-piperidinecarboxylic acid 2-propen-1-yl ester
EINECS	Contact for details

Quality Control

Our Btk Kinase Inhibitor is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing identity, purity, and strength is provided with every shipment to ensure compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and potency. Allow the vial to equilibrate to room temperature in a desiccator before opening.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.